PRN: New Post Hoc Analyses of Pivotal Trials of Safinamide on Motor Complications and Pain in Advancing Parkinson's Disease

14/gen/2016 14.01.04 PR Newswire Turismo Contatta l'autore

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New Post Hoc Analyses of Pivotal Trials of Safinamide on Motor Complications and Pain in Advancing Parkinson's Disease

 
[14-January-2016]
 

LONDON, January 14, 2016 /PRNewswire/ --

European Neurological Review, the peer-reviewed journal, has published a review highlighting the effects of safinamide on motor complications and pain in advancing Parkinson's disease. The review, in particular, summarises lessons learned from recent post hoc analyses of pivotal trials.

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Chronic levodopa (l-dopa) treatment of Parkinson's disease (PD) patients is associated with motor complications (fluctuations and dyskinesias), which limit l-dopa efficacy and require drug therapy adjustments. Moreover, patients often experienced many non-motor symptoms, such as pain, which have a major impact on their quality of life. The neuropathology of PD has shown that complex, interconnected neuronal systems, regulated by a number of different neurotransmitters in addition to dopamine, are involved in the aetiology of motor and non-motor symptoms. Safinamide is a water-soluble, orally active aminoamide derivative that modulates dopaminergic and glutamatergic neurotransmission with a new and unique dual mechanism of action. Safinamide has been recently approved by the European Medicines Agency for the treatment of fluctuating PD patients as add-on therapy to l-dopa alone or in combination with other antiparkinson drugs. This article summarises the results of the pos! t hoc analyses of the long-term efficacy of safinamide on motor complications and pain performed in three pivotal clinical trials.

The full peer-reviewed, open-access article is available here:

http://doi.org/10.17925/ENR.2015.10.02.176

Note to the Editor

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European Neurological Review, a peer-reviewed, open access, bi-annual journals specialising in the publication of balanced and comprehensive review articles written by leading authorities to address the most important and salient developments in the field of neurology. The aim of these reviews is to break down the high science from 'data-rich' primary papers and provide practical advice and opinion on how this information can help physicians in the day to day clinical setting. Practice guidelines, symposium write-ups, case reports, and original research articles are also featured to promote discussion and learning amongst physicians, clinicians, researchers and related healthcare professionals.

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