PRN: Enhancing Patient Outcomes- Practical Approaches to Treatment Optimisation in Parkinson's Disease

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Enhancing Patient Outcomes- Practical Approaches to Treatment Optimisation in Parkinson's Disease


LONDON, January 17, 2017 /PRNewswire/ --

Claudia Trenkwalder, Stuart H Isaacson, Georg Ebersbach

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European Neurological Review, 2016;11(Suppl.3):2-7;

Published recently in European Neurological Review, the peer-reviewed journal from touchNEUROLOGY, Claudia Trenkwalder et al, reports on a symposium, chaired by Claudia Trenkwalder (Germany), covering the most practical and effective approaches to enhance the outcomes of Parkinson's disease (PD) patients across all disease stages. Despite taking multiple oral medications to control the symptoms of PD, many patients experience significant OFF time each day, with troublesome motor fluctuations and dyskinesias, that impact their quality of life. Stuart Isaacson (US) discussed how to optimise ON time in PD patients once fluctuations start. He highlighted the importance of considering non-oral routes of administration of PD medication to avoid gastrointestinal issues that are common in PD and can affect medication absorption. He rev! iewed the results of the AM-IMPAKT (Apokyn for Motor IMProvement of morning AKinesia Trial) study, which demonstrated that delayed ON and dose failure due to poor absorption of oral levodopa can be rapidly and reliably overcome with subcutaneous apomorphine injection. Georg Ebersbach (Germany) considered the later stages of disease and the management of patients who require continuous dopaminergic stimulation. Using case study illustrations, he advised how to select the correct form of advanced therapy for patients, highlighting the importance of continuous review and monitoring to optimise their outcomes.

The full peer-reviewed, open-access article is available here:

Disclosure: Claudia Trenkwalder has received personal fees for advisory boards from Mundipharma, UCB, Vifor Pharma, Britannia Pharmaceuticals, Novartis; payments for lectures from UCB, Astra Zeneca, Desitin, Mundipharma, Abbvie; royalties from Schattauer Verlag. Stuart H Isaacson has received honoraria for CME activities, research grants and/or consultant and promotional speaker fees from AbbVie, Acadia, Adamas, Addex, Allergan, Allon, AstraZeneca, Biotie, Britannia, Chelsea, Civitas, Eisai, GE, GSK, Impax, Ipsen, Kyowa, Lilly, Merck Schering-Plough, Medtronics, Merz, Michael J Fox Foundation, Novartis, Neurocrine, National Institutes of Health (NIH), Novartis, Orion, Parkinson Study Group, Phytopharm, Purdue, Roche, Santhera, Serono, Shire, Teva, UCB and US World Meds. Georg Ebersbach has received consultancies from AOK Nordost; honoraria for advisory boards from UCB Pharma, AbbVie Pharma, Grünenthal Pha! rma; speaker's honoraria from AbbVie Pharma, Britannia Pharma, Desitin Pharma, Grünenthal Pharma, Licher GmbH, Mundipharma, TEVA Pharma, UCB Pharma, Zambon Pharma; royalties from Kohlhammer Verlag. This article reports the proceedings of a sponsored satellite symposium held at the 20th International Congress of Parkinson's Disease and Movement Disorders, Berlin, Germany and, as such, has not been subject to this journal's usual peer-review process. A member of the editorial board reviewed the report before publication.

Note to the Editor

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European Neurological Review, a peer-reviewed, open access, bi-annual journal specialising in the publication of balanced and comprehensive review articles written by leading authorities to address the most important and salient developments in the field of neurology. The aim of these reviews is to break down the high science from 'data-rich' primary papers and provide practical advice and opinion on how this information can help physicians in the day to day clinical setting. Practice guidelines, symposium write-ups, case reports, and original research articles are also featured to promote discussion and learning amongst physicians, clinicians, researchers and related healthcare professionals.

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